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    Revista SCientifica

    versión impresa ISSN 1813-0054

    Resumen

    GUTIERREZ CHOQUE, Bismar Jorge. Response to Vascular Endothelial Inflammation, Hypoxia and Sepsis. SCIENTIFICA [online]. 2016, vol.14, n.1, pp. 44-48. ISSN 1813-0054.

    Alterations in endothelial cells and vasculature play an important part in the pathogenesis of a broad spectrum of human morbid conditions; consequently endothelial cells play a key role in the maintenance of capillary functionality. The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance, chronic renal failure, tumor growth, metastasis, venous thrombosis and severe infectious diseases. Therefore, vascular endothelium dysfunctions are a characteristic of human diseases. An inflammation is a response to the aggression of a harmful or potentially harmful agent can either be physical, chemical or biological. In an inflammation there are a number of processes that aim to repair the aflected area so the endothelium responds with vascular and cellular changes. The vascular changes are associated with changes in the size and vascular flow; cellular changes, with expression molecules on the surface of endothelial cells that facilitate the passage of immune system cells into the extravascular space. Endothelium participates as sensor activating the hypoxia-induced factors (HIF), in response to hypoxia, which begin a process of transcribing the Factor molecules Vascular Endothelial Growth factor (VEGF) and erythropoietin (EPO) which have physiological functions in response to this state of low oxygen concentration. In sepsis, endothelium dysfunction undergoes a state in which it is unable to establish a proper vascular tone and proper flow to the tissues, causing shock and ultimately multiple organ failure. In this review, the main endothelial abnormalities found in situations such as sepsis, inflammatory response and the hypoxic phenomenon are discussed.

    Palabras llave : Endothelium; inflammation; hypoxia; sepsis.

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